Salmon Nasal Cartilage-Derived Proteoglycans Alleviate Cartilage Degeneration in Osteoarthritis by Modulating Inflammation and Apoptosis.
Salmon cartilage-derived proteoglycans show promise in treating osteoarthritis by reducing inflammation, preserving cartilage, and preventing cell death - a potential game-changer for managing this debilitating joint condition.
This study investigated the therapeutic potential of proteoglycans (PG) extracted from salmon nasal cartilage in both in vitro and in vivo models of osteoarthritis (OA). In the in vivo rat model, PG treatment significantly improved cartilage structure, decreased inflammatory markers, and attenuated apoptotic signaling pathways. The findings suggest that PG can protect articular cartilage by mitigating inflammation, preserving cartilage integrity, and preventing chondrocyte cell death. This study supports the potential of PG as a promising treatment option for OA, providing both anti-inflammatory and chondroprotective effects. Limitations include the need for further clinical trials to validate the efficacy and safety of PG in human OA patients.