Demineralization Promotes Changes on Bone Surface that Improve Osteoblasts' Growth.
Bone demineralization unlocks surface secrets that supercharge osteoblasts, accelerating bone graft integration and healing. This discovery could revolutionize orthopedic treatments.
This study investigated the effects of bone demineralization on osteoblast behavior. Bone samples from rat calvaria were treated with 10% or 50% citric acid, or saline solution. Cells cultured on demineralized surfaces showed improved morphology and spreading compared to controls. Microscopy analysis revealed that demineralization altered surface parameters like peak-to-valley and peak-to-peak distances, without affecting roughness or mineral content. These structural changes appear to create an optimal environment for pre-osteoblast growth and differentiation, with potential to enhance bone graft consolidation and regenerative therapies.