Assembly of 1,3-diaryl-1<i>H</i>-pyrazoles <i>via</i> base-mediated [3 + 2] cycloaddition.
Unlock the power of 1,3-diaryl-1H-pyrazoles with a novel, metal-free synthesis! This versatile scaffold shines in pharma, materials, and agro, and this study delivers an efficient, scalable [3+2] cycloaddition route. Prepare to revolutionize your research.
This study presents a transition metal-free protocol for the synthesis of 1,3-diaryl-1H-pyrazoles, a valuable heterocyclic scaffold. The method involves base-catalyzed [3+2] cycloaddition of hydrazones and vinyl sulfoxides, followed by oxidation. The reaction exhibits broad substrate scope and was successfully scaled up to the gram scale. Further investigations confirmed the practicality and scalability of this synthetic approach, paving the way for diverse applications in pharmaceutical development, functional materials, and agrochemical industries.