Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.
Pelota, a ribosome rescue factor, unlocks the secret to longevity and age-defying health across species. This discovery sheds light on how quality control in protein synthesis can combat cellular dysfunction and age-related diseases.
This research paper investigates the role of Pelota, a key player in ribosome-associated quality control (RQC), in regulating lifespan and age-related pathologies. Through genetic screening in C. elegans, the study found that Pelota is essential for longevity. Further experiments demonstrated that Pelota mitigates premature senescence in human cells, muscle aging in mice, and neurodegeneration in Alzheimer's disease models. Mechanistically, Pelota maintains autophagy-mediated proteostasis by preventing the hyperactivation of the mTOR signaling pathway. This work highlights the conserved importance of RQC, regulated by Pelota, in extending lifespan and protecting diverse species against age-associated diseases, opening new avenues for therapeutic interventions.