Self-Assembled Nanoconjugates with Aggregation-Induced Emission for Near-Infrared II Imaging and Transcytosis-Driven Cancer Therapy.
Innovative nanoconjugates with aggregation-induced emission enable real-time NIR-II imaging to guide transcytosis-driven cancer therapy, revolutionizing nanomedicine's clinical impact.
This research developed a multifunctional nanoparticle platform that combines a paclitaxel-polymer conjugate with aggregation-induced emission (AIE) luminogens. The nanoparticles exhibited high drug loading, intense near-infrared II (NIR-II) fluorescence, and enhanced tumor accumulation due to the zwitterionic tertiary amine oxide (TAO) moiety. The platform allowed dynamic visualization of tumor penetration via NIR-II imaging and achieved deep tumor infiltration and suppressed tumor growth in a mouse model, bridging diagnostic certainty with therapeutic efficacy. This translatable strategy offers a promising approach for image-guided precision oncology.